GARRE1

granule associated Rac and RHOG effector 1

Tier: Gold Standard Ciliary Genes

Ensembl:
ENSG00000282735
UniProt:
O15063
OMIM:
619335
Synonyms:
KIAA0355, MINIBAR

Cilia effects upon perturbation of GARRE1

Cilia number / % ciliated:
Decreased cilia number
Loss-of-function effect:
Shorter cilia

Phenotypes

Mouse phenotype:
hyperactivity

Subcellular localization

basal body, cilia

References: PMID:37875118

Functional category

  • Ciliary assembly/disassembly
  • Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
  • Cilia length regulation

Function

MiniBAR (also known as KIAA0355/GARRE1) is a dual Rab/Rac effector with a truncated BAR domain. MiniBAR promotes cilia elongation by controlling the delivery of ciliary cargos. MiniBAR also determines cilia length by limiting cellular acto-myosin contractility. MiniBAR depletion leads to left-right asymmetry defects and signs of ciliopathy in vivo.48 h after induction of ciliogenesis, the proportion of ciliated cells was modestly but reproducibly decreased upon MiniBAR depletion. Importantly, cilia length was significantly reduced (37875118).