GDF15

Cilia effects upon perturbation of GDF15

Loss-of-function effect:

Shorter cilia

Ciliogenesis screen results (5 screens)

• Kim2016: Not Reported
• Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-3.71) PMID:26167766
• Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
• Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
• Elliott et al. 2025 (CRISPRa) [CRISPRa]: Disassembly Trigger (casTLE Effect=-3.61) PMID:41160700

Subcellular localization

cilia associated gene

Functional category

• Ciliary assembly/disassembly
• Cell migration & adhesion
• Signaling (Hedgehog, GPCRs, ion channels)
• Cardiac & muscle development

Function

Alteration in ciliary function and modulation of ADCY3 and GDF15 have all been linked to the regulation of energy homeostasis, food intake, and obesity (37064917).GDF15 critically contributes to the regulation of primary cilia in apical progenitors and neural stem cells (NSCs) in the embryonic ganglionic eminence (GE) and in the adult ventricular-subventricular zone (V-SVZ)(38719753).