GDI2

GDP dissociation inhibitor 2

Tier: Gold Standard Ciliary Genes

Ensembl:: ENSG00000057608
UniProt:: P50395
OMIM:: 600767
Synonyms:: RABGDIB

Ciliogenesis screen results (4 screens)

Kim2016: Not Reported
Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-3.89) PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Mouse phenotype:: preweaning lethality, complete penetrance, impaired glucose tolerance

Subcellular localization

basal body, cytosol

References: PMID:25860027

Functional category

Ciliary assembly/disassembly
Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
Actin & cytoskeleton regulation

Function

zip1 was phosphorylated by GSK3β at S520 in G0 phase, which increased its binding to GDI2 to promote the release of Rab8GDP at the cilium base(25860027).

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