GDI2

GDP dissociation inhibitor 2

Ensembl:: ENSG00000057608
UniProt:: P50395
OMIM:: 600767
Synonyms:: RABGDIB

Cilia effects upon perturbation of GDI2

Ciliogenesis screen results (4 screens)

Kim2016: Not Reported
Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-3.89) PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Mouse phenotype:: preweaning lethality, complete penetrance, impaired glucose tolerance
Mouse ciliopathy phenotype:: cataract, abnormal lens morphology, abnormal reti blood vessel morphology, abnormal reti vasculature morphology, abnormal reti morphology, abnormal vitreous body morphology

Subcellular localization

basal body, cytosol

Functional category

Ciliary assembly/disassembly
Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
Actin & cytoskeleton regulation

Function

zip1 was phosphorylated by GSK3尾 at S520 in G0 phase, which increased its binding to GDI2 to promote the release of Rab8GDP at the cilium base(25860027).

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