GFAP
glial fibrillary acidic protein
- Ensembl:
- ENSG00000131095
- UniProt:
- P14136
- OMIM:
- 137780
- Synonyms:
- FLJ45472
Cilia effects upon perturbation of GFAP
- Cilia number / % ciliated:
- No effect
Ciliogenesis screen results (3 screens)
- Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-4.24) PMID:26167766
- Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
- Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
Subcellular localization
cilia, cytosol
Functional category
- Ciliary assembly/disassembly
- Actin & cytoskeleton regulation
- Neurogenesis & migration
Function
GFAP positive astrocytes possessed cilia specific markers adenylyl cyclase III (ACIII)(31249512) More than 90% of the GFAP-positive cells formed primary cilia, and the primary cilium formation rate remained unchanged
Model organism evidence
Mus musculus (2 references)
Immunocytochemistry localized acid sphingomyelinase (ASM), a ceramide-generating enzyme, to ependymal cilia, suggesting these sites as a potential source of EVs.
Hedgehog signaling drives glial cell plasticity and oncogenic reprogramming in gastroenteropancreatic neuroendocrine neoplasms.