GFAP

glial fibrillary acidic protein

Tier: Gold Standard Ciliary Genes

Ensembl:
ENSG00000131095
UniProt:
P14136
OMIM:
137780
Synonyms:
FLJ45472

Cilia effects upon perturbation of GFAP

Cilia number / % ciliated:
No effect

Ciliogenesis screen results (3 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-4.24) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Subcellular localization

cilia, cytosol

References: PMID:25860027

Functional category

  • Ciliary assembly/disassembly
  • Actin & cytoskeleton regulation
  • Neurogenesis & migration

Function

GFAP positive astrocytes possessed cilia specific markers adenylyl cyclase III (ACIII)(31249512) More than 90% of the GFAP-positive cells formed primary cilia, and the primary cilium formation rate remained unchanged