GGA1

golgi associated, gamma adaptin ear containing, ARF binding protein 1

Ensembl:: ENSG00000100083
UniProt:: Q9UJY5
OMIM:: 606004

Cilia effects upon perturbation of GGA1

Ciliogenesis screen results (4 screens)

Kim2016: Not Reported
Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-5.76) PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Mouse ciliopathy phenotype:: abnormal auditory brainstem response, abnormal testis morphology, male infertility, small testis

Subcellular localization

cilia associated gene, endosome, nucleus

Functional category

Ciliary assembly/disassembly
Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
Ciliary membrane

Function

Rabep1/GGA1/Arl3-dependent ciliary targeting mechanism, whereby Rabep1 couples the polycystin complex to a GGA1/Arl3-based ciliary trafficking module at the TGN ( 25405894).

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