GIGYF1

GRB10 interacting GYF protein 1

Ensembl:
ENSG00000146830
UniProt:
O75420
OMIM:
612064
Synonyms:
GYF1, PERQ1

Cilia effects upon perturbation of GIGYF1

Ciliogenesis screen results (2 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-2.08) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Phenotypes

Mouse phenotype:
preweaning lethality, incomplete penetrance, preweaning lethality, complete penetrance

Subcellular localization

basal body, cilia

Functional category

  • Ciliary assembly/disassembly
  • Actin & cytoskeleton regulation
  • Signaling (Hedgehog, GPCRs, ion channels)

Function

GIGYF1 has localized in basal body, cilia. GIGYF1 is annotated to “Cilium organization” in ciliated cells.(36189799)