GLOD4

glyoxalase domain containing 4

Ensembl:: ENSG00000167699
UniProt:: Q9HC38
OMIM:: 620650
Synonyms:: C17ORF25, CGI-150, HC71

Cilia effects upon perturbation of GLOD4

Loss-of-function effect:: Shorter cilia

Ciliogenesis screen results (2 screens)

Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Subcellular localization

cilia associated gene, mitochondria

Functional category

Ciliary assembly/disassembly
Cilia length regulation

Function

GLOD4 is required for proper ciliogenesis ( 23604077). Knockdown of GLOD4 in RPE1 cells reduces cilia length and affects cell cycle progression. ( 23604077)

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