GMNC

geminin coiled-coil domain containing

Ensembl:
ENSG00000205835
UniProt:
A6NCL1
OMIM:
614448
Synonyms:
GEMC1

Cilia effects upon perturbation of GMNC

Ciliogenesis screen results (2 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Phenotypes

Mouse phenotype:
increased circulating sodium level, increased grip strength

Subcellular localization

cilia, lysosomes

Functional category

  • Ciliary assembly/disassembly
  • Actin & cytoskeleton regulation

Function

Also known as GEMC1. Regulator of multiciliated cells differentiation, interacting with E2F4/5鈥怐P1 and Multicilin. Candidate gene for human reduced generation of multiple motile cilia RGMC (26933123). It transactivates the McIdas and FoxJ1 upstream regulatory sequences, markers of ciliogenesis (26882546).

Model organism evidence

Mus musculus (1 reference)

Mouse Zfp423 mutants display a marked reduction of the hindbrain ChP (hChP), which: (1) fails to express established markers of its secretory function and genes implicated in its development and maintenance (Lmx1a and Otx2); (2) shows a perturbed expression of signaling pathways previously unexp

PMIDs: 33046507