GMNC

geminin coiled-coil domain containing

Tier: Gold Standard Ciliary Genes

Ensembl:
ENSG00000205835
UniProt:
A6NCL1
OMIM:
614448
Synonyms:
GEMC1

Ciliogenesis screen results (2 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Phenotypes

Mouse phenotype:
increased circulating sodium level, increased grip strength

Subcellular localization

cilia, lysosomes

References: PMID:26933123, PMID:26882546

Functional category

  • Ciliary assembly/disassembly
  • Actin & cytoskeleton regulation

Function

Also known as GEMC1. Regulator of multiciliated cells differentiation, interacting with E2F4/5‐DP1 and Multicilin. Candidate gene for human reduced generation of multiple motile cilia RGMC (26933123). It transactivates the McIdas and FoxJ1 upstream regulatory sequences, markers of ciliogenesis (26882546).