GNAI3

G protein subunit alpha i3

Ensembl:
ENSG00000065135
UniProt:
P08754
OMIM:
139370
Synonyms:
87U6

Cilia effects upon perturbation of GNAI3

Ciliogenesis screen results (4 screens)

  • Kim2016: No effect
  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-3.44) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Subcellular localization

basal body, centrosome

Functional category

  • Ciliary assembly/disassembly
  • Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
  • Viral interactions
  • Signaling (Hedgehog, GPCRs, ion channels)

Function

G I3 has localized in basal body.

Model organism evidence

Mus musculus (1 reference)

Here we describe the generation of an Espin overexpressing transgenic mouse line that results in longer first row stereocilia and discoordination of second-row stereocilia length.

PMIDs: 35844198