GOPC

golgi associated PDZ and coiled-coil motif containing

Ensembl:
ENSG00000047932
UniProt:
Q9HD26
OMIM:
606845
Synonyms:
CAL, DJ94G16.2, FIG, GOPC1, PIST

Cilia effects upon perturbation of GOPC

Ciliogenesis screen results (4 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
  • Elliott et al. 2025 (CRISPRa) [CRISPRa]: Disassembly Trigger (casTLE Effect=-5.46) PMID:41160700

Phenotypes

Mouse phenotype:
enlarged cecum, abnormal cecum morphology, preweaning lethality, incomplete penetrance, increased circulating phosphate level
Mouse ciliopathy phenotype:
decreased circulating calcium level

Subcellular localization

flagella

Functional category

  • Trafficking (BBSome, small GTPases, vesicular transport, ATPases)

Function

GOPC has localized in flagella.

Model organism evidence

Mus musculus (1 reference)

Gopc-/- infertile globozoospermic murine model has failures during spermiogenesis, such as the incorrect biogenesis of the acrosome, disorganized acroplaxome and manchette, round nuclei and spiral flagella.

PMIDs: 34870349