GOPC

golgi associated PDZ and coiled-coil motif containing

Tier: Gold Standard Ciliary Genes

Ensembl:: ENSG00000047932
UniProt:: Q9HD26
OMIM:: 606845
Synonyms:: CAL, DJ94G16.2, FIG, GOPC1, PIST

Ciliogenesis screen results (4 screens)

Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
Elliott et al. 2025 (CRISPRa) [CRISPRa]: Disassembly Trigger (casTLE Effect=-5.46) PMID:41160700

Phenotypes

Mouse phenotype:: enlarged cecum, abnormal cecum morphology, preweaning lethality, incomplete penetrance, increased circulating phosphate level

Subcellular localization

flagella

References: PMID:25613900

Functional category

Trafficking (BBSome, small GTPases, vesicular transport, ATPases)

Function

GOPC has localized in flagella.

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