GPR161

G protein-coupled receptor 161

Tier: Gold Standard Ciliary Genes

Ensembl:: ENSG00000143147
UniProt:: Q8N6U8
OMIM:: 612250
Synonyms:: RE2

Ciliogenesis screen results (3 screens)

Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-5.67) PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Ciliopathy associations

Holoprosencephaly
Medulloblastoma

References: PMID:25322266

Subcellular localization

basal body, cilia, transition zone

References: PMID:41005307, PMID:23332756

Functional category

Ciliary assembly/disassembly
Signaling (Hedgehog, GPCRs, ion channels)
Ciliary membrane
Transition zone

Function

GPR161 increases cAMP levels, establishing the basal cAMP gradient and activation of PKA. Repression of Shh signaling by determining the processing of Gli3 to its repressor form (23332756).

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