GPR161
G protein-coupled receptor 161
- Ensembl:
- ENSG00000143147
- UniProt:
- Q8N6U8
- OMIM:
- 612250
- Synonyms:
- RE2
Cilia effects upon perturbation of GPR161
Ciliogenesis screen results (3 screens)
- Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-5.67) PMID:26167766
- Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
- Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
Ciliopathy associations
- Holoprosencephaly
- Medulloblastoma
Subcellular localization
basal body, cilia, transition zone
Functional category
- Ciliary assembly/disassembly
- Signaling (Hedgehog, GPCRs, ion channels)
- Ciliary membrane
- Transition zone
Function
GPR161 increases cAMP levels, establishing the basal cAMP gradient and activation of PKA. Repression of Shh sig ling by determining the processing of Gli3 to its repressor form (23332756).
Model organism evidence
Mus musculus (2 references)
Loss of the primary cilium-localized G protein-coupled receptor GPR161 causes ectopic, excessive hedgehog signaling in the mouse neural tube and fully penetrant exencephaly.
Linkage between Fuz and Gpr161 genes regulates sonic hedgehog signaling during mouse neural tube development.