GPR173

G protein-coupled receptor 173

Tier: Gold Standard Ciliary Genes

Ensembl:: ENSG00000184194
UniProt:: Q9NS66
OMIM:: 300253
Synonyms:: SREB3

Ciliogenesis screen results (3 screens)

Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-6.26) PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Mouse phenotype:: abnormal skin coloration, abnormal coat appearance, hyperactivity

Subcellular localization

basal body, cilia

References: PMID:26167768

Functional category

Ciliary assembly/disassembly
Cell migration & adhesion
Signaling (Hedgehog, GPCRs, ion channels)

Function

Also known as SREB3. Neuronal ciliary GPCR which may play sensory or signalling roles in the ciliary vesicle or procilium during ciliogenesis

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