GPR183

G protein-coupled receptor 183

Tier: Gold Standard Ciliary Genes

Ensembl:
ENSG00000169508
UniProt:
P32249
OMIM:
605741
Synonyms:
EBI2

Ciliogenesis screen results (2 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-5.18) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Phenotypes

Mouse phenotype:
increased hematocrit, increased erythrocyte cell number

Subcellular localization

cilia, ciliary tip

References: PMID:41005307

Functional category

  • Ciliary assembly/disassembly
  • Cell migration & adhesion
  • Signaling (Hedgehog, GPCRs, ion channels)

Function

GPR183 has localized in cilia.