GPR19

G protein-coupled receptor 19

Tier: Gold Standard Ciliary Genes

Ensembl:: ENSG00000183150
UniProt:: Q15760
OMIM:: 602927

Ciliogenesis screen results (5 screens)

Kim2016: Not Reported
Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-2.11) PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
Pusapati et al. 2018 (CRISPR) [CRISPR]: Positive Regulator (Hh signaling, neg_rank=46, lfc=-2.63) PMID:30270045

Subcellular localization

cilia

References: PMID:28154160, PMID:36699005

Functional category

Ciliary assembly/disassembly
Signaling (Hedgehog, GPCRs, ion channels)

Function

Gpr19 is an orphan GPCR that also localizes to cilia on hippocampal neurons (28154160) and Gpr19 accumulate in cilia on Bbs1 knockout neurons(36699005).

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