GPR19

G protein-coupled receptor 19

Ensembl:
ENSG00000183150
UniProt:
Q15760
OMIM:
602927

Cilia effects upon perturbation of GPR19

Ciliogenesis screen results (5 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-2.11) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
  • Pusapati et al. 2018 (CRISPR) [CRISPR]: Positive Regulator (Hh signaling, neg_rank=46, lfc=-2.63) PMID:30270045

Subcellular localization

cilia

Functional category

  • Ciliary assembly/disassembly
  • Signaling (Hedgehog, GPCRs, ion channels)

Function

Gpr19 is an orphan GPCR that also localizes to cilia on hippocampal neurons (28154160) and Gpr19 accumulate in cilia on Bbs1 knockout neurons(36699005).

Model organism evidence

Mus musculus (1 reference)

Ciliary signaling proteins are mislocalized in the brains of Bardet-Biedl syndrome 1-null mice.

PMIDs: 36699005