GPR63

G protein-coupled receptor 63

Ensembl:
ENSG00000112218
UniProt:
Q9BZJ6
Synonyms:
PSP24(BETA), PSP24B

Cilia effects upon perturbation of GPR63

Cilia number / % ciliated:
No effect

Ciliogenesis screen results (3 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-5.17) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Mouse ciliopathy phenotype:
increased circulating alanine transamise level, decreased circulating calcium level

Subcellular localization

cilia

Functional category

  • Ciliary assembly/disassembly
  • Signaling (Hedgehog, GPCRs, ion channels)

Function

Gpr63 interacts with Ttc21b to modify the size of the forebrain in Ttc21baln/aln null mutants and provide evidence that the Gpr63 mutation is the likely causal variant for the chromosome 4 QTL affecting brain size(31730647). Overexpression of Gpr63 variants did not appear to affect the number of cells producing cilia (31730647)

Model organism evidence

Mus musculus (1 reference)

The primary cilium is a signaling center critical for proper embryonic development.

PMIDs: 31730647