GPR63

G protein-coupled receptor 63

Tier: Gold Standard Ciliary Genes

Ensembl:
ENSG00000112218
UniProt:
Q9BZJ6
Synonyms:
PSP24(BETA), PSP24B

Cilia effects upon perturbation of GPR63

Cilia number / % ciliated:
No effect

Ciliogenesis screen results (3 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-5.17) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Subcellular localization

cilia

References: PMID:31730647

Functional category

  • Ciliary assembly/disassembly
  • Signaling (Hedgehog, GPCRs, ion channels)

Function

Gpr63 interacts with Ttc21b to modify the size of the forebrain in Ttc21baln/aln null mutants and provide evidence that the Gpr63 mutation is the likely causal variant for the chromosome 4 QTL affecting brain size(31730647). Overexpression of Gpr63 variants did not appear to affect the number of cells producing cilia (31730647)