GPR83

G protein-coupled receptor 83

Ensembl:: ENSG00000123901
UniProt:: Q9NYM4
OMIM:: 605569
Synonyms:: GPR72

Cilia effects upon perturbation of GPR83

Ciliogenesis screen results (4 screens)

Kim2016: Not Reported
Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-7.70) PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Mouse phenotype:: decreased memory-marker cd4-positive nk t cell number, enlarged thymus, decreased body weight, abnormal spleen morphology, abnormal thymus morphology, decreased nk t cell number, enlarged spleen, impaired glucose tolerance, decreased cd4-positive nk t cell number
Mouse ciliopathy phenotype:: abnormal liver morphology, abnormal brain morphology

Subcellular localization

basal body, cilia

Functional category

Ciliary assembly/disassembly
Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
Signaling (Hedgehog, GPCRs, ion channels)

Function

Suggested to belong to NPY receptor family, which shares common determi nts for ciliary trafficking

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