GPR88

G protein-coupled receptor 88

Ensembl:
ENSG00000181656
UniProt:
Q9GZN0
OMIM:
607468

Cilia effects upon perturbation of GPR88

Cilia number / % ciliated:
No effect
Loss-of-function effect:
No effect

Ciliogenesis screen results (4 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-5.80) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Subcellular localization

basal body

Functional category

  • Ciliary assembly/disassembly
  • Signaling (Hedgehog, GPCRs, ion channels)
  • Ciliary membrane

Function

Regulation of D1 dopamine receptor (D1R) sig ling to inhibit cAMP accumulation, whitout affecting B2AR- mediated response. Cilia formation and length were similar between GPR88 knockout and wild-type animals. (40501619)