GPRC5A

G protein-coupled receptor class C group 5 member A

Tier: Gold Standard Ciliary Genes

Ensembl:
ENSG00000013588
UniProt:
Q8NFJ5
OMIM:
604138
Synonyms:
PEIG-1, RAI3, RAIG1, TIG1

Ciliogenesis screen results (2 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-2.67) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Subcellular localization

cilia, ciliary tip

References: PMID:41005307, PMID:35695071

Functional category

  • Ciliary assembly/disassembly
  • Signaling (Hedgehog, GPCRs, ion channels)

Function

GPRC5A has localized in cilia. GPRC5A is included in a cAMP signalosome in primary cilia. (35695071)