GPRC5C

G protein-coupled receptor class C group 5 member C

Tier: Gold Standard Ciliary Genes

Ensembl:
ENSG00000170412
UniProt:
Q9NQ84
OMIM:
605949
Synonyms:
RAIG-3

Cilia effects upon perturbation of GPRC5C

Loss-of-function effect:
Abnormal / altered cilia

Ciliogenesis screen results (3 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-4.22) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Subcellular localization

cilia, transition zone

References: PMID:41005307, PMID:38110903

Functional category

  • Ciliary assembly/disassembly
  • Signaling (Hedgehog, GPCRs, ion channels)

Function

GPRC5C regulates olfactory cilia composition and length, thereby controlling odour perception(38110903). GPRC5C deficiency altered the structure of sensory cilia and increased ciliary layer thickness (