GPSM1

G protein signaling modulator 1

Tier: Gold Standard Ciliary Genes

Ensembl:: ENSG00000160360
UniProt:: Q86YR5
OMIM:: 609491
Synonyms:: AGS3, DKFZP727I051

Ciliogenesis screen results (3 screens)

Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Mouse phenotype:: decreased bronchoconstrictive response, decreased body length, decreased pulmory ventilation, abnormal skin morphology

Subcellular localization

cilia, cytosol

References: PMID:23954591

Functional category

Ciliary assembly/disassembly
Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
Actin & cytoskeleton regulation
Transition zone

Function

Also known as AGS3. Regulation fo Gβgamma signaling pathway to recruits phospho(T94)Tctex-1 to the transition zone. Stabilises the GDP-bound form of Gαi wit IGF-1R to prevent its re- association with Gβgamma and mantain it free.

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