GPSM1

G protein signaling modulator 1

Ensembl:
ENSG00000160360
UniProt:
Q86YR5
OMIM:
609491
Synonyms:
AGS3, DKFZP727I051

Cilia effects upon perturbation of GPSM1

Ciliogenesis screen results (3 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Mouse phenotype:
decreased bronchoconstrictive response, decreased body length, decreased pulmory ventilation, abnormal skin morphology
Mouse ciliopathy phenotype:
abnormal kidney morphology

Subcellular localization

cilia, cytosol

Functional category

  • Ciliary assembly/disassembly
  • Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
  • Actin & cytoskeleton regulation
  • Transition zone

Function

Also known as AGS3. Regulation fo G尾gamma sig ling pathway to recruits phospho(T94)Tctex-1 to the transition zone. Stabilises the GDP-bound form of G伪i wit IGF-1R to prevent its re- association with G尾gamma and mantain it free.

Model organism evidence

C. elegans (2 references)

We identify ODR-3 as the RIC-8 Gα client and demonstrate that RIC-8 functions in the same genetic pathway with another component of the non-canonical G protein signaling AGS-3 to shape cilia morphology.

PMIDs: 37910589, 37662329