GPSM2

G protein signaling modulator 2

Tier: Cilia-Associated Genes

Ensembl:: ENSG00000121957
OMIM:: 609245
Synonyms:: DFNB82, LGN, PINS

Phenotypes

Mouse phenotype:: abnormal retina morphology, cataract, abnormal vitreous body morphology, abnormal lens morphology

Subcellular localization

Centrosome, Cytosol

References: PMID:33258871

Functional category

Motors (dynein/kinesin)
Ciliary assembly/disassembly

Function

Smo activates the Gαi-LGN-NuMA-dynein axis, causing accumulation of a portion of OFD1 at centrioles in early ciliogenesis. Both pathways are critical for redistribution of BBS4 from satellites to centrioles, which is also mediated by OFD1 centriolar translocation. Notably, different Smo agonists, which activate Smo distinctly, activate one or the other of these pathways, only in combination they recapitulate the activity of Hh ligand. These studies provide new insight into physiological stimuli (Hh) that activate autophagy and promote ciliogenesis and introduce a novel role for the Gαi-LGN-NuMA-dynein complex in this process(33258871).

Note: Additional interactive sections (perturbation matrix visualization, phylogenetic conservation strip, protein complex network, STRING interactions) require JavaScript. Browse CiliaHub for the full experience.