GRAP

GRB2 related adaptor protein

Ensembl:
ENSG00000154016
UniProt:
Q13588
OMIM:
604330

Cilia effects upon perturbation of GRAP

Ciliogenesis screen results (3 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-4.81) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Subcellular localization

basal body, cytosol

Functional category

  • Ciliary assembly/disassembly
  • Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
  • Signaling (Hedgehog, GPCRs, ion channels)

Function

GRAP localized to basal body (25613900)

Model organism evidence

Drosophila (1 reference)

Flagellar growth continued within the short rn null cysts to produce large bulbous terminations of intertwined mature flagella.

PMIDs: 11509670