GRB2

growth factor receptor bound protein 2

Tier: Gold Standard Ciliary Genes

Ensembl:: ENSG00000177885
UniProt:: P62993
OMIM:: 108355
Synonyms:: NCKAP2

Ciliogenesis screen results (4 screens)

Kim2016: No effect
Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-5.48) PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: Increased Signaling (Negative Regulator) PMID:29459680
Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Mouse phenotype:: preweaning lethality, complete penetrance, abnormal behavior

Subcellular localization

cilia, cytosol, nucleus

References: PMID:41005307

Functional category

Ciliary assembly/disassembly
Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
Actin & cytoskeleton regulation
Viral interactions
Signaling (Hedgehog, GPCRs, ion channels)

Function

GRB2 has localized in primary cilia. Grb2 controls phosphorylation of FGFR2 by inhibiting receptor kinase and Shp2 phosphatase activity (23420874)

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