GRB2

growth factor receptor bound protein 2

Ensembl:
ENSG00000177885
UniProt:
P62993
OMIM:
108355
Synonyms:
NCKAP2

Cilia effects upon perturbation of GRB2

Ciliogenesis screen results (4 screens)

  • Kim2016: No effect
  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-5.48) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: Increased Signaling (Negative Regulator) PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Mouse phenotype:
preweaning lethality, complete penetrance, abnormal behavior

Subcellular localization

cilia, cytosol, nucleus

Functional category

  • Ciliary assembly/disassembly
  • Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
  • Actin & cytoskeleton regulation
  • Viral interactions
  • Signaling (Hedgehog, GPCRs, ion channels)

Function

GRB2 has localized in primary cilia. Grb2 controls phosphorylation of FGFR2 by inhibiting receptor kinase and Shp2 phosphatase activity (23420874)

Model organism evidence

Drosophila (1 reference)

Flagellar growth continued within the short rn null cysts to produce large bulbous terminations of intertwined mature flagella.

PMIDs: 11509670