GRHL3

grainyhead like transcription factor 3

Ensembl:: ENSG00000158055
UniProt:: Q8TE85
OMIM:: 608317
Synonyms:: SOM, TFCP2L4

Cilia effects upon perturbation of GRHL3

Ciliogenesis screen results (2 screens)

Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Phenotypes

Mouse phenotype:: decreased circulating alkaline phosphatase level, abnormal eye morphology, increased startle reflex, decreased blood urea nitrogen level, increased circulating glucose level, decreased circulating triglyceride level, increased circulating phosphate level, preweaning lethality, complete penetrance, increased circulating calcium level, abnormal locomotor activation, increased circulating amylase level
Mouse ciliopathy phenotype:: abnormal reti morphology

Subcellular localization

cilia, nucleus

Functional category

Ciliary assembly/disassembly
Actin & cytoskeleton regulation
Transcription regulation

Function

GRHL3 has localized in primary cilia.

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