GRIP1

glutamate receptor interacting protein 1

Ensembl:: ENSG00000155974
UniProt:: Q9Y3R0
OMIM:: 604597

Cilia effects upon perturbation of GRIP1

Ciliogenesis screen results (3 screens)

Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Subcellular localization

cilia associated gene, cytosol

Functional category

Ciliary assembly/disassembly
Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
Actin & cytoskeleton regulation
Signaling (Hedgehog, GPCRs, ion channels)

Function

ARL3T31A/C118F mutations downregulate IQUB, RAB3IP, GRIP1, and UNC13D, leading to significantly elongated cilia and impaired retrograde transport of cilia ( 38457249).

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