GRK1

G protein-coupled receptor kinase 1

Tier: Gold Standard Ciliary Genes

Ensembl:: ENSG00000281988
UniProt:: Q15835
OMIM:: 180381
Synonyms:: GPRK1, RHOK, RK

Ciliogenesis screen results (4 screens)

Kim2016: Not Reported
Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-3.87) PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Subcellular localization

flagella

References: PMID:25422369, PMID:25550383

Functional category

Signaling (Hedgehog, GPCRs, ion channels)

Function

Phosphorylation of opsins, playing a key role in the shutdown of the rod and cone cascades ( 25422369). Peripherally associated proteins anchored to the membrane by lipid modifications. It inactivates rhodopsin through phosphorylation ( 25550383).

Note: Additional interactive sections (perturbation matrix visualization, phylogenetic conservation strip, protein complex network, STRING interactions) require JavaScript. Browse CiliaHub for the full experience.