GRK7
G protein-coupled receptor kinase 7
Tier: Gold Standard Ciliary Genes
- Ensembl:
- ENSG00000114124
- UniProt:
- Q8WTQ7
- OMIM:
- 606987
- Synonyms:
- GPRK7
Ciliogenesis screen results (1 screens)
- Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
Ciliopathy associations
- Retinal Dystrophy/Degeneration
References: PMID:38646933
Subcellular localization
cilia, golgi apparatus
Functional category
- Signaling (Hedgehog, GPCRs, ion channels)
Function
GRK7 was detected in the apical side of cilia and OS-like structures, colocalizing with PRPH2. EYS plays a role in the trafficking of an OS protein, G protein–coupled receptor kinase 7 (GRK7), which is evolutionarily conserved along with EYS and involved in photoresponse recovery (27, 28). EYS-RD organoids and zebrafish exhibited light-induced photoreceptor cell death related to GRK7 deprivation in the OS. Furthermore, light-induced cell death in RD organoids was especially caused by blue light(PMID: 38646933, 36273582).; Mutations in GRK7 cause Retinal Dystrophy (PMID: 38646933).