GRM1

glutamate metabotropic receptor 1

Ensembl:
ENSG00000152822
UniProt:
Q13255
OMIM:
604473
Synonyms:
GPRC1A, MGLU1, MGLUR1, PPP1R85

Cilia effects upon perturbation of GRM1

Ciliogenesis screen results (4 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
  • Elliott et al. 2025 (CRISPRa) [CRISPRa]: Disassembly Trigger (casTLE Effect=-2.24) PMID:41160700

Phenotypes

Human ciliopathy phenotype:
autosomal recessive spinocerebellar ataxia 13; autosomal dominant cerebellar ataxia; Autosomal recessive congenital cerebellar ataxia due to MGLUR1 deficiency; Autosomal recessive cerebellar ataxia-pyramidal signs-nystagmus-oculomotor apraxia syndrome; spinocerebellar ataxia 44; Adult-onset autosomal recessive cerebellar ataxia

Subcellular localization

cilia associated gene, nucleus

Functional category

  • Ciliary assembly/disassembly
  • Signaling (Hedgehog, GPCRs, ion channels)

Function

Mutations in the GRM1 gene cause Spinocerebellar Ataxia (PMID: 29100096).