GRM5

Tier: Gold Standard Ciliary Genes

Ensembl:: ENSG00000168959
UniProt:: P41594
OMIM:: 604102
Synonyms:: mGluR5, mGlu5, GPRC1E, glutamate metabotropic receptor 5

Subcellular localization

ciliary membrane

Function

Metabotropic glutamate receptor 5 (mGluR5), a class C GPCR. Validated by immunostaining to localize to neuronal primary cilia (Chang et al. 2026, Sci Adv); enriched in glutamatergic/GABAergic neuron cilia, implicating ciliary metabotropic glutamate sensing.

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