GSN

gelsolin

Ensembl:
ENSG00000148180
UniProt:
P06396
OMIM:
137350
Synonyms:
DKFZP313L0718

Cilia effects upon perturbation of GSN

Cilia number / % ciliated:
Decreased cilia number
Loss-of-function effect:
Unknown
Overexpression effect:
Unknown

Ciliogenesis screen results (3 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-4.61) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Subcellular localization

cilia associated gene

Functional category

  • Ciliary assembly/disassembly
  • Actin & cytoskeleton regulation
  • T cell biology
  • Viral interactions
  • Protein processing & maturation
  • Signaling (Hedgehog, GPCRs, ion channels)
  • Cardiac & muscle development
  • Muscle contraction & physiology

Function

Among the ciliogenesis modulators with high confirmation screen scores are two Gelsolin (GSN) family proteins GSN and AVIL, which regulate cytoskeletal actin organization by severing actin filaments11. Depletion of GSN proteins by two independent siRNAs significantly reduced ciliated cell numbers, suggesting that actin filament severing is involved in ciliogenesis (20393563).