GSTM3

glutathione S-transferase mu 3

Tier: Gold Standard Ciliary Genes

Ensembl:
ENSG00000134202
UniProt:
P21266
OMIM:
138390
Synonyms:
GST5, GSTM3TV2

Ciliogenesis screen results (5 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-3.54) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
  • Kim et al. 2010 (siRNA) [siRNA]: Longer Cilia (Area per Cilia z=3.64) PMID:20393562

Phenotypes

Mouse phenotype:
increased circulating alkaline phosphatase level, decreased exploration in new environment, increased circulating serum albumin level

Subcellular localization

cilia, cytosol, nucleus, transition zone, ciliary tip

References: PMID:41005307, PMID:8242618

Functional category

  • Ciliary assembly/disassembly
  • Reproduction & sperm
  • Cardiac & muscle development
  • Transition zone

Function

GSTM3 has localized in ciliary tip, transition zone. GSTM3, an enzyme of broad extrahepatic occurrence, was observable in the ciliated airway epithelium and smooth muscle of the lung. (8242618)