GTSF1

gametocyte specific factor 1

Ensembl:: ENSG00000170627
UniProt:: Q8WW33
OMIM:: 617484
Synonyms:: CUE110, FAM112B, FLJ32942

Cilia effects upon perturbation of GTSF1

Ciliogenesis screen results (2 screens)

Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Ciliopathy associations

Male Infertility

Subcellular localization

cilia associated gene, nucleoplasm

Functional category

Reproduction & sperm

Function

GTSF1 are involved in flagellum development; for normal sperm motility(PMID: 35173218). The Gtsf1/Cue110-null mice grew normally and appeared healthy; however, the males were sterile due to massive apoptotic death of their germ cells after postnatal day 14. In contrast, the null females were fertile. Detailed analyses revealed that the Gtsf1/Cue110-null male meiocytes ceased meiotic progression before the zygotene stage. Thus, the Gtsf1/Cue110 gene is essential for spermatogenesis beyond the early meiotic phase(PMID: 19735653).

Note: Additional interactive sections (perturbation matrix visualization, phylogenetic conservation strip, protein complex network, STRING interactions) require JavaScript. Browse CiliaHub for the full experience.