GUCA1B

guanylate cyclase activator 1B

Ensembl:
ENSG00000112599
UniProt:
Q9UMX6
OMIM:
602275
Synonyms:
GCAP-2, GCAP-II, GCAP2, RP48

Cilia effects upon perturbation of GUCA1B

Ciliogenesis screen results (3 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-5.70) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Human ciliopathy phenotype:
retinitis pigmentosa

Subcellular localization

basal body

Functional category

  • Ciliary assembly/disassembly
  • Signaling (Hedgehog, GPCRs, ion channels)

Function

GUCA1B has localized in basal body.