HASPIN
histone H3 associated protein kinase
Tier: Cilia-Associated Genes
- Ensembl:
- ENSG00000177602
- UniProt:
- Q8TF76
- OMIM:
- 609240
- Synonyms:
- GSG2
Cilia effects upon perturbation of HASPIN
- Loss-of-function effect:
- Longer cilia
Subcellular localization
No ciliary localization reported (cilia-associated gene).
References: PMID:34299370
Functional category
- Ciliary assembly/disassembly
- Actin & cytoskeleton regulation
Function
Haspin is active in quiescent cells, where it phosphorylates threonine 3 of histone H3, a known mitotic Haspin substrate. Forcing Dido3 detachment from the chromatin prevents Haspin inhibition from impacting cilia dynamics, suggesting that Haspin activity is required for the relocalization of Dido3–HDAC6 to the basal body ( 34299370). Cells defective in Haspin activity exhibit longer primary cilia and a strong delay in cilia resorption upon cell cycle reentry. (34299370)