HASPIN

Cilia effects upon perturbation of HASPIN

Loss-of-function effect:

Longer cilia

Subcellular localization

cilia associated gene

Functional category

• Ciliary assembly/disassembly
• Actin & cytoskeleton regulation
• T cell biology

Function

Haspin is active in quiescent cells, where it phosphorylates threonine 3 of histone H3, a known mitotic Haspin substrate. Forcing Dido3 detachment from the chromatin prevents Haspin inhibition from impacting cilia dy mics, suggesting that Haspin activity is required for the relocalization of Dido3–HDAC6 to the basal body ( 34299370). Cells defective in Haspin activity exhibit longer primary cilia and a strong delay in cilia resorption upon cell cycle reentry. (34299370)

Model organism evidence