HAVCR1

hepatitis A virus cellular receptor 1

Tier: Gold Standard Ciliary Genes

Ensembl:: ENSG00000113249
UniProt:: Q96D42
OMIM:: 606518
Synonyms:: CD365, HAVCR, HAVCR-1, KIM1, TIM-1, TIM1, TIMD1

Ciliogenesis screen results (4 screens)

Kim2016: Not Reported
Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-4.44) PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Subcellular localization

cilia

References: PMID:20375059, PMID:18273441, PMID:17205356

Functional category

Ciliary assembly/disassembly
Viral interactions
Signaling (Hedgehog, GPCRs, ion channels)

Function

Also known as KIM1. Biomarker of proximal tubular injury. Depletion does not disturb cilia formation (20375059). Modulates cilary calcium signaling and plays a role in ciliary flow sensing (18273441: 17205356).

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