HAVCR1

hepatitis A virus cellular receptor 1

Ensembl:
ENSG00000113249
UniProt:
Q96D42
OMIM:
606518
Synonyms:
CD365, HAVCR, HAVCR-1, KIM1, TIM-1

Cilia effects upon perturbation of HAVCR1

Ciliogenesis screen results (4 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-4.44) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Subcellular localization

cilia

Functional category

  • Ciliary assembly/disassembly
  • T cell biology
  • Viral interactions
  • Signaling (Hedgehog, GPCRs, ion channels)

Function

Also known as KIM1. Biomarker of proximal tubular injury. Depletion does not disturb cilia formation (20375059). Modulates cilary calcium sig ling and plays a role in ciliary flow sensing (18273441: 17205356).

Model organism evidence

Mus musculus (1 reference)

Mice homozygous for an iNPH-associated AK9 mutation displayed normal cilia structure and number, but decreased cilia motility and beat frequency, communicating hydrocephalus, and balance impairment.

PMIDs: 38100419