HDAC2

Cilia effects upon perturbation of HDAC2

Cilia number / % ciliated:

Incrased cilia number

Loss-of-function effect:

Decreased cilia number

Ciliogenesis screen results (3 screens)

• Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-3.01) PMID:26167766
• Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
• Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Mouse phenotype:

preweaning lethality, complete penetrance, unresponsive to tactile stimuli, no spontaneous movement

Subcellular localization

cilia associated gene, nucleus

Functional category

• Ciliary assembly/disassembly
• Neurogenesis & migration
• Viral interactions
• Cell migration & adhesion
• Signaling (Hedgehog, GPCRs, ion channels)
• Cardiac & muscle development
• Transcription regulation

Function

HDAC2 contributes to suppression of primary cilia formation by controlling Aurora A levels in a Kras‐independent manner in PDAC cells( 28028031). Inhibition or silencing of histone deacetylase 2 (HDAC2) restores primary cilia formation in PDAC cells. (28028031) Ectopic activation of AurkA and HDAC2 accounts for reduced cilia in KC ADM cells. (32571902)