HDAC3

Cilia effects upon perturbation of HDAC3

Cilia number / % ciliated:

Decreased cilia number

Loss-of-function effect:

Shorter cilia

Ciliogenesis screen results (6 screens)

• Kim2016: Not Reported
• Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
• Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
• Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
• Pusapati et al. 2018 (CRISPR) [CRISPR]: Positive Regulator (Hh signaling, neg_rank=729, lfc=-2.40) PMID:30270045
• Kim et al. 2010 (siRNA) [siRNA]: Shorter Cilia (Area per Cilia z=-2.33) PMID:20393562

Phenotypes

Mouse phenotype:

preweaning lethality, complete penetrance, decreased erythrocyte cell number, decreased hemoglobin content, decreased hematocrit, increased circulating ldl cholesterol level

Subcellular localization

cilia associated gene

Functional category

• Ciliary assembly/disassembly
• Actin & cytoskeleton regulation
• Viral interactions
• Protein processing & maturation
• Signaling (Hedgehog, GPCRs, ion channels)
• Cardiac & muscle development
• Transcription regulation

Function

HDAC3 and HDAC8 are required for the assembly and elongation of the primary cilia(31362948).