HDAC6

Cilia effects upon perturbation of HDAC6

Cilia number / % ciliated:

Unknown

Loss-of-function effect:

Unknown

Overexpression effect:

Shorter cilia

Ciliogenesis screen results (3 screens)

• Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
• Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
• Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Subcellular localization

basal body, cytosol, microtubules, nucleus

Functional category

• Ciliary assembly/disassembly
• Actin & cytoskeleton regulation
• T cell biology
• Neurogenesis & migration
• Protein processing & maturation
• Cell migration & adhesion
• Signaling (Hedgehog, GPCRs, ion channels)
• Axon guidance & growth
• Transcription regulation
• Cilia length regulation

Function

Regulation of ciliary resorption in response to extracelullar stress and it is also a downstream AurA effector. Destabilises the microtubular axoneme through deacetylation of tubulin, which promotes ciliary disassembly (17604723, 24026243). Mediates an autophagy- dependent mechanism called ciliophagy (24200693) Overexpression on Cilia Length: Decreases cilia length. The study shows that increased levels of HDAC6 lead directly to the shortening and disassembly of connecting cilia.LoF on Cilia Length: Prevents stress-induced cilia shortening. In HDAC6 knockout mice, cilia length is maintained even under the oxygen-induced stress that causes disassembly in normal mice. Percentage of Ciliated Cells: Overexpression decreases the density (percentage) of ciliated cells, while a loss-of-function maintains the normal density.

Model organism evidence