HIF1AN

hypoxia inducible factor 1 subunit alpha inhibitor

Tier: Cilia-Associated Genes

Ensembl:: ENSG00000166135
UniProt:: Q9NWT6
OMIM:: 606615
Synonyms:: DKFZP762F1811, FIH1, FLJ20615, FLJ22027

Ciliogenesis screen results (4 screens)

Kim2016: Not Reported
Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Mouse phenotype:: preweaning lethality, incomplete penetrance, small liver, abnormal eye morphology, abnormal skin morphology, abnormal coat/hair pigmentation, increased startle reflex, abnormal bone structure, decreased exploration in new environment, decreased prepulse inhibition, abnormal spleen morphology, increased neutrophil cell number, enlarged spleen

Subcellular localization

cytosol, nucleus

References: PMID:25671767

Functional category

Ciliary assembly/disassembly
Signaling (Hedgehog, GPCRs, ion channels)
Transcription regulation

Function

HIF1AN is not localized to cilia, but it is functionally related to ciliary processes through interactions with proteins like ANKS3 and NPHPs ( 25671767).

Note: Additional interactive sections (perturbation matrix visualization, phylogenetic conservation strip, protein complex network, STRING interactions) require JavaScript. Browse CiliaHub for the full experience.