HINT1

histidine triad nucleotide binding protein 1

Ensembl:
ENSG00000169567
UniProt:
P49773
OMIM:
601314
Synonyms:
HINT, PKCI-1, PRKCNH1

Cilia effects upon perturbation of HINT1

Ciliogenesis screen results (4 screens)

  • Kim2016: No effect
  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-7.06) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: Hyper-ciliogenesis (robust z=2.08, ciliated=53.6%) PMID:26595381

Phenotypes

Mouse phenotype:
decreased erythrocyte cell number, tremors, increased startle reflex, decreased circulating glycerol level

Subcellular localization

cilia associated gene, mitochondria, nucleus

Functional category

  • Ciliary assembly/disassembly
  • Transcription regulation

Function

PKCI particularly have role in the regulation of ciliary beat frequency (CBF)( 11066030).