HIP1

huntingtin interacting protein 1

Tier: Gold Standard Ciliary Genes

Ensembl:: ENSG00000127946
UniProt:: O00291
OMIM:: 601767
Synonyms:: ILWEQ

Ciliogenesis screen results (3 screens)

Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Mouse phenotype:: decreased circulating creatinine level, increased bone mineral content, abnormal gait, decreased locomotor activity, abnormal cornea morphology, hyperactivity, abnormal vertebrae morphology, decreased vertical activity, cornea opacity, decreased startle reflex, decreased body length

Subcellular localization

flagella, nucleus

References: PMID:25613900

Functional category

Actin & cytoskeleton regulation
Signaling (Hedgehog, GPCRs, ion channels)

Function

HIP1 localized to flagella (25613900)

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