HIP1

huntingtin interacting protein 1

Ensembl:
ENSG00000127946
UniProt:
O00291
OMIM:
601767
Synonyms:
ILWEQ

Cilia effects upon perturbation of HIP1

Ciliogenesis screen results (3 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Mouse phenotype:
decreased circulating creatinine level, increased bone mineral content, abnormal gait, decreased locomotor activity, abnormal cornea morphology, hyperactivity, abnormal vertebrae morphology, decreased vertical activity, cornea opacity, decreased startle reflex, decreased body length

Subcellular localization

flagella, nucleus

Functional category

  • Actin & cytoskeleton regulation
  • Signaling (Hedgehog, GPCRs, ion channels)

Function

HIP1 localized to flagella (25613900)

Model organism evidence

Mus musculus (1 reference)

Remaining spermatids revealed deformations of their heads, flagella, and/or acrosomes.

PMIDs: 16967501