HK1

hexokinase 1

Ensembl:: ENSG00000156515
UniProt:: P19367
OMIM:: 142600

Cilia effects upon perturbation of HK1

Ciliogenesis screen results (4 screens)

Kim2016: Not Reported
Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-3.48) PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Human ciliopathy phenotype:: retinitis pigmentosa

Subcellular localization

cilia associated gene, cytosol

Functional category

Ciliary assembly/disassembly
Metabolism

Function

Mutations in the HK1 gene cause Retinitis Pigmentosa (PMID: 25316723).

Model organism evidence

Mus musculus (1 reference)

We have characterized novel proteins that have their expression controlled by PAIP2A; of these, 50% are involved in flagellar structure and sperm motility.

PMIDs: 22190698

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