HMGB1

high mobility group box 1

Ensembl:
ENSG00000189403
UniProt:
P09429
OMIM:
163905
Synonyms:
DKFZP686A04236, HMG1, HMG3, SBP-1

Cilia effects upon perturbation of HMGB1

Cilia number / % ciliated:
Decreased cilia number
Loss-of-function effect:
Shorter cilia

Ciliogenesis screen results (4 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Subcellular localization

cilia associated gene, endosome, nucleus

Functional category

  • Ciliary assembly/disassembly
  • Actin & cytoskeleton regulation
  • Metabolism
  • T cell biology
  • Viral interactions
  • Cell migration & adhesion
  • Signaling (Hedgehog, GPCRs, ion channels)
  • Transcription regulation

Function

HMGB1 affected cilia formation in 2.5D culture. EW-7197, AG-1478 and the TNFα antibody prevented the increase in cell metabolism induced by HMGB1 and inflammatory cytokines in 2D culture ( 33182652). Frequency and length of neuronal primary cilia were quantitatively analyzed … we observed a decrease and shortening of neuronal primary cilia in APP mutant iPSC neurons treated with HMGB1. (34635772) The disruption of the epithelial barrier including cilia formation induced by HMGB1 contributed to TGF-β signaling in Caco-2 cells. (34538217)