HMGB4

high mobility group box 4

Ensembl:: ENSG00000176256
UniProt:: Q8WW32
OMIM:: 617285
Synonyms:: FLJ40388

Cilia effects upon perturbation of HMGB4

Ciliogenesis screen results (2 screens)

Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Ciliopathy associations

Male Infertility

Subcellular localization

cilia associated gene

Functional category

Metabolism

Function

HMGB4, POC1B, PKM, LDHA, TBC1D21, and CBY2, which were associated with spermatogenesis, sperm flagellar structure, and energy metabolism, and can be used as candidate markers for predicting the motility of buffalo spermatozoa(PMID: 39961484).

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