HOXD13
homeobox D13
Tier: Cilia-Associated Genes
- Ensembl:
- ENSG00000128714
- UniProt:
- P35453
- OMIM:
- 142989
- Synonyms:
- HOX4I, SPD
Cilia effects upon perturbation of HOXD13
- Loss-of-function effect:
- Abnormal / altered cilia
Subcellular localization
nucleus
Function
HOXD13 is selectively expressed in synovial fibroblasts from distal joints and regulates primary cilia function; its silencing alters cilia-dependent Hedgehog (GLI) signaling, cell-cycle control and DNA damage responses, and joints differ in primary cilia morphology (PMID 42778485).