HSD11B1

hydroxysteroid 11-beta dehydrogenase 1

Tier: Gold Standard Ciliary Genes

Ensembl:
ENSG00000117594
UniProt:
P28845
OMIM:
600713
Synonyms:
HSD11, HSD11B, SDR26C1

Ciliogenesis screen results (4 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Subcellular localization

basal body, transition zone

References: PMID:30340023

Functional category

  • Ciliary assembly/disassembly
  • Signaling (Hedgehog, GPCRs, ion channels)
  • Transition zone

Function

oxysterol synthase HSD11β2 participates in the production of Smoothened-activating cilia-localised oxysterols and promotes Hedgehog pathway activity.