HSD3B1

hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1

Tier: Gold Standard Ciliary Genes

Ensembl:
ENSG00000203857
UniProt:
P14060
OMIM:
109715
Synonyms:
HSD3B, HSDB3, SDR11E1

Ciliogenesis screen results (4 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-3.08) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Subcellular localization

cilia, transition zone

References: PMID:41005307

Functional category

  • Ciliary assembly/disassembly

Function

An enzyme that is part of sterol synthesis, HSD3B1/HSD3B2 also found in several enzymes in cilia