HSPA1A

heat shock protein family A (Hsp70) member 1A

Ensembl:
ENSG00000234475, ENSG00000215328, ENSG00000235941, ENSG00000204389, ENSG00000237724
UniProt:
P0DMV9
OMIM:
140550
Synonyms:
HSP70-1, HSPA1

Cilia effects upon perturbation of HSPA1A

Loss-of-function effect:
Inhibition restores cilium length

Ciliogenesis screen results (4 screens)

  • Kim2016: No effect
  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-10.86) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: Hyper-ciliogenesis (robust z=2.33, ciliated=55.5%) PMID:26595381

Subcellular localization

basal body, centrosome, cytosol, nucleus

Functional category

  • Ciliary assembly/disassembly
  • Actin & cytoskeleton regulation
  • Metabolism
  • T cell biology
  • Viral interactions
  • Protein processing & maturation
  • Signaling (Hedgehog, GPCRs, ion channels)
  • Transcription regulation

Function

YFP-tagged HSPA6 and HSPA1A were detected in prominent structures resembling centrioles in the cytoplasm of post-mitotic, differentiating human neurons (24061851). Following a brief period of thermal stress, YFP-tagged HSPA6 and HSPA1A rapidly appeared at centrioles in the cytoplasm of human neuronal cells. (24061851) The HSPA1A inhibitor pifithrin-µ restores cilium length in WDR4 patient cells. (39251572)