HSPA1B

heat shock protein family A (Hsp70) member 1B

Tier: Gold Standard Ciliary Genes

Ensembl:
ENSG00000212866
UniProt:
P0DMV9
OMIM:
603012
Synonyms:
HSP70-2

Ciliogenesis screen results (4 screens)

  • Kim2016: No effect
  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-3.97) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: Hyper-ciliogenesis (robust z=2.59, ciliated=57.5%) PMID:26595381

Subcellular localization

basal body, centrosome, cytosol, flagella, nucleus

References: PMID:25613900

Functional category

  • Ciliary assembly/disassembly
  • Actin & cytoskeleton regulation
  • Metabolism
  • Viral interactions
  • Protein processing & maturation
  • Signaling (Hedgehog, GPCRs, ion channels)
  • Transcription regulation

Function

HSPA1B has localized in basal body,flagella.