HSPA8

heat shock protein family A (Hsp70) member 8

Tier: Gold Standard Ciliary Genes

Ensembl:
ENSG00000109971
UniProt:
P11142
OMIM:
600816
Synonyms:
HSC70, HSC71, HSP73, HSPA10

Ciliogenesis screen results (4 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-5.93) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Subcellular localization

basal body, cilia, cytosol, nucleus, transition zone

References: PMID:19302411

Functional category

  • Ciliary assembly/disassembly
  • Actin & cytoskeleton regulation
  • Metabolism
  • Viral interactions
  • Protein processing & maturation
  • Signaling (Hedgehog, GPCRs, ion channels)
  • Cardiac & muscle development
  • Transition zone
  • Transcription regulation

Function

Also called HSC70. Function in the formation or stabilization of IFT-cargo complexes working with MRJ. It may bind directly to IFT88 or to one or more additional TPR containing proteins within the IFT particle, which in turn recruit MRJ bound cargo proteins (19302411).