HSPA8

heat shock protein family A (Hsp70) member 8

Ensembl:
ENSG00000109971
UniProt:
P11142
OMIM:
600816
Synonyms:
HSC70, HSC71, HSP73, HSPA10

Cilia effects upon perturbation of HSPA8

Ciliogenesis screen results (4 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-5.93) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Subcellular localization

basal body, cilia, cytosol, nucleus, transition zone

Functional category

  • Ciliary assembly/disassembly
  • Actin & cytoskeleton regulation
  • Metabolism
  • Viral interactions
  • Protein processing & maturation
  • Signaling (Hedgehog, GPCRs, ion channels)
  • Cardiac & muscle development
  • Transition zone
  • Transcription regulation

Function

Also called HSC70. Function in the formation or stabilization of IFT-cargo complexes working with MRJ. It may bind directly to IFT88 or to one or more additio l TPR containing proteins within the IFT particle, which in turn recruit MRJ bound cargo proteins (19302411).